JAK-STAT and feeding

JAK-STAT and feeding

The regulation of energy balance requires a complex system to homeostatically maintain the adult body at a precise set point. The central nervous system, particularly the hypothalamus, plays a key role in integrating a variety of signals that can relay information about the body's energy stores. As part of this system, numerous cytokines and hormones contribute to the regulation of food intake ...

JAK-STAT pathway and JAK inhibitors: a primer for dermatologists

Background: All cellular events depend upon the DNA synthesis and gene expression involving complex interplay between ligands such as interleukins and interferons, with various cell membrane receptors. These ligand-receptors interactions transmit signals within the cell via numerous signal transduction pathways to affect gene expression. Janus kinase/signal transducer and activator of transcrip...

Jak-stat

90 JAK-STAT Volume 1 issue 2 In this issue of JAK-STAT, we introduce a series of reviews overlooking the ever-expanding field of myocardial JAK-STAT signaling. The history of cardiac JAK-STAT research begins in the mid-nineties, when various groups began to focus their attention on how myocardial physiology was specifically regulated through JAK-STAT signaling. Interest in the area began to gro...

SnapShot: JAK-STAT Signaling

JAK-STAT and bone metabolism

Emerging evidences suggest Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway plays an important role in bone development and metabolism. Effects of JAK-STAT pathway on skeletal development are summarized based on skeletal phenotype of individual JAK and STAT gene knockout mouse. Furthermore, STAT3 has more profound effects on bone homeostasis compared ...